SAAD Digest 

September 2025
Volume: 41
Issue: 2
DOI: 10.63507/OODO3230

Title: Peri-operative management of dental patients requiring procedural sedation and taking Ozempic®, Mounjaro®, or other glucagon-like peptide-1 receptor agonist- containing medication

Author(s):  I. Khan

Abstract: 
The rising number of prescriptions for glucagon-like peptide-1 receptor agonists and glucose-dependent insulinotropic polypeptide receptor agonists is due to expanding indications and increased demand. These medications can cause delayed gastric emptying and increase the risk of pulmonary aspiration, particularly during deep sedation and general anaesthesia. Special care patients, such as those with Parkinson's disease or cerebral palsy, are at higher risk. This paper examines the pharmacology of glucagon-like peptide-1 receptor agonists and glucose-dependent insulinotropic polypeptide receptor agonists, assesses the risk of pulmonary aspiration under procedural sedation, reviews current guidance from anaesthetic societies and suggests methods to mitigate risks for patients on these medications during procedural sedation.

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Articles from Digest 41(II)